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Scorpion β-toxin interference with Na(V) channel voltage sensor gives rise to excitatory and depressant modes
Scorpion β toxins, peptides of ∼70 residues, specifically target voltage-gated sodium (Na(V)) channels to cause use-dependent subthreshold channel openings via a voltage–sensor trapping mechanism. This excitatory action is often overlaid by a not yet understood depressant mode in which Na(V) channel...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Rockefeller University Press
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315148/ https://www.ncbi.nlm.nih.gov/pubmed/22450487 http://dx.doi.org/10.1085/jgp.201110720 |