Microtubules as a Critical Target for Arsenic Toxicity in Lung Cells in Vitro and in Vivo

To understand mechanisms for arsenic toxicity in the lung, we examined effects of sodium m-arsenite (As(3+)) on microtubule (MT) assembly in vitro (0–40 µM), in cultured rat lung fibroblasts (RFL6, 0–20 µM for 24 h) and in the rat animal model (intratracheal instillation of 2.02 mg As/kg body weight...

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Detalles Bibliográficos
Autores principales: Zhao, Yinzhi, Toselli, Paul, Li, Wande
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315258/
https://www.ncbi.nlm.nih.gov/pubmed/22470304
http://dx.doi.org/10.3390/ijerph9020474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315258/
https://www.ncbi.nlm.nih.gov/pubmed/22470304
http://dx.doi.org/10.3390/ijerph9020474

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