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Microtubules as a Critical Target for Arsenic Toxicity in Lung Cells in Vitro and in Vivo
To understand mechanisms for arsenic toxicity in the lung, we examined effects of sodium m-arsenite (As(3+)) on microtubule (MT) assembly in vitro (0–40 µM), in cultured rat lung fibroblasts (RFL6, 0–20 µM for 24 h) and in the rat animal model (intratracheal instillation of 2.02 mg As/kg body weight...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315258/ https://www.ncbi.nlm.nih.gov/pubmed/22470304 http://dx.doi.org/10.3390/ijerph9020474 |