Naphthyridine tetramer with a pre-organized structure for 1:1 binding to a CGG/CGG sequence

A naphthyridine carbamate dimer (NCD) is a synthetic ligand for DNA containing a CGG/CGG sequence. Although NCD can bind selectively and tightly to a CGG/CGG sequence, the highly cooperative 2:1 binding mode has hampered precise analysis of the binding. We describe herein the synthesis of a series o...

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Detalles Bibliográficos
Autores principales: Dohno, Chikara, Kohyama, Izumi, Hong, Changfeng, Nakatani, Kazuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315301/
https://www.ncbi.nlm.nih.gov/pubmed/22127864
http://dx.doi.org/10.1093/nar/gkr1148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315301/
https://www.ncbi.nlm.nih.gov/pubmed/22127864
http://dx.doi.org/10.1093/nar/gkr1148

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