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Collective Dynamics Differentiates Functional Divergence in Protein Evolution

Protein evolution is most commonly studied by analyzing related protein sequences and generating ancestral sequences through Bayesian and Maximum Likelihood methods, and/or by resurrecting ancestral proteins in the lab and performing ligand binding studies to determine function. Structural and dynam...

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Detalles Bibliográficos
Autores principales: Glembo, Tyler J., Farrell, Daniel W., Gerek, Z. Nevin, Thorpe, M. F., Ozkan, S. Banu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315450/
https://www.ncbi.nlm.nih.gov/pubmed/22479170
http://dx.doi.org/10.1371/journal.pcbi.1002428