Gene Reactivation by 5-Aza-2′-Deoxycytidine–Induced Demethylation Requires SRCAP–Mediated H2A.Z Insertion to Establish Nucleosome Depleted Regions

5-Aza-2′-deoxycytidine, approved by the FDA for the treatment of myelodysplastic syndrome (MDS), is incorporated into the DNA of dividing cells where it specifically inhibits DNA methylation by forming covalent complexes with the DNA methyltransferases (DNMTs). In an effort to study the correlations...

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Detalles Bibliográficos
Autores principales: Yang, Xiaojing, Noushmehr, Houtan, Han, Han, Andreu-Vieyra, Claudia, Liang, Gangning, Jones, Peter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315468/
https://www.ncbi.nlm.nih.gov/pubmed/22479200
http://dx.doi.org/10.1371/journal.pgen.1002604

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315468/
https://www.ncbi.nlm.nih.gov/pubmed/22479200
http://dx.doi.org/10.1371/journal.pgen.1002604

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