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Probing the Informational and Regulatory Plasticity of a Transcription Factor DNA–Binding Domain
Transcription factors have two functional constraints on their evolution: (1) their binding sites must have enough information to be distinguishable from all other sequences in the genome, and (2) they must bind these sites with an affinity that appropriately modulates the rate of transcription. Sin...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315485/ https://www.ncbi.nlm.nih.gov/pubmed/22496663 http://dx.doi.org/10.1371/journal.pgen.1002614 |