A Cytoplasmic Tail Determinant in HIV-1 Vpu Mediates Targeting of Tetherin for Endosomal Degradation and Counteracts Interferon-Induced Restriction

The HIV-1 accessory protein Vpu counteracts tetherin (BST-2/CD317) by preventing its incorporation into virions, reducing its surface expression, and ultimately promoting its degradation. Here we characterize a putative trafficking motif, EXXXLV, in the second alpha helix of the subtype-B Vpu cytopl...

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Detalles Bibliográficos
Autores principales: Kueck, Tonya, Neil, Stuart J. D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315493/
https://www.ncbi.nlm.nih.gov/pubmed/22479182
http://dx.doi.org/10.1371/journal.ppat.1002609

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315493/
https://www.ncbi.nlm.nih.gov/pubmed/22479182
http://dx.doi.org/10.1371/journal.ppat.1002609

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