Expression of Constitutively Active CDK1 Stabilizes APC-Cdh1 Substrates and Potentiates Premature Spindle Assembly and Checkpoint Function in G1 Cells

Mitotic progression in eukaryotic cells depends upon the activation of cyclin-dependent kinase 1 (CDK1), followed by its inactivation through the anaphase-promoting complex (APC)/cyclosome-mediated degradation of M-phase cyclins. Previous work revealed that expression of a constitutively active CDK1...

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Detalles Bibliográficos
Autores principales: Ma, Yan, Yuan, Xi, Wyatt, William R., Pomerening, Joseph R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315497/
https://www.ncbi.nlm.nih.gov/pubmed/22479455
http://dx.doi.org/10.1371/journal.pone.0033835

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315497/
https://www.ncbi.nlm.nih.gov/pubmed/22479455
http://dx.doi.org/10.1371/journal.pone.0033835

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