Cargando…
Identification of Novel Mt-Guab2 Inhibitor Series Active against M. tuberculosis
Tuberculosis (TB) remains a leading cause of mortality worldwide. With the emergence of multidrug resistant TB, extensively drug resistant TB and HIV-associated TB it is imperative that new drug targets be identified. The potential of Mycobacterium tuberculosis inosine monophosphate dehydrogenase (I...
Autores principales: | Usha, Veeraraghavan, Hobrath, Judith V., Gurcha, Sudagar S., Reynolds, Robert C., Besra, Gurdyal S. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315515/ https://www.ncbi.nlm.nih.gov/pubmed/22479467 http://dx.doi.org/10.1371/journal.pone.0033886 |
Ejemplares similares
-
Inhibition of Escherichia coli glycosyltransferase MurG and Mycobacterium tuberculosis Gal transferase by uridine-linked transition state mimics
por: Trunkfield, Amy E., et al.
Publicado: (2010) -
Novel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput phenotypic screen
por: Cox, Jonathan A. G., et al.
Publicado: (2016) -
Biochemical and Structural Characterization of Mycobacterial Aspartyl-tRNA Synthetase AspS, a Promising TB Drug Target
por: Gurcha, Sudagar S., et al.
Publicado: (2014) -
Mycolic Acid Modification by the mmaA4 Gene of M. tuberculosis Modulates IL-12 Production
por: Dao, Dee N., et al.
Publicado: (2008) -
Ppm1-Encoded Polyprenyl Monophosphomannose Synthase Activity Is Essential for Lipoglycan Synthesis and Survival in Mycobacteria
por: Rana, Amrita K., et al.
Publicado: (2012)