Mutations in the phosphatidylinositol 3-kinase pathway: role in tumor progression and therapeutic implications in breast cancer

Mutations in genes that constitute the phosphatidylinositol 3-kinase (PI3K) pathway occur in >70% of breast cancers. Clinical and experimental evidence suggest that PI3K pathway activation promotes resistance to some of the current breast cancer therapies. PI3K is a major signaling hub downstream...

Descripción completa

Detalles Bibliográficos
Autores principales: Miller, Todd W, Rexer, Brent N, Garrett, Joan T, Arteaga, Carlos L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315683/
https://www.ncbi.nlm.nih.gov/pubmed/22114931
http://dx.doi.org/10.1186/bcr3039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315683/
https://www.ncbi.nlm.nih.gov/pubmed/22114931
http://dx.doi.org/10.1186/bcr3039

Ejemplares similares