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Mutations in the phosphatidylinositol 3-kinase pathway: role in tumor progression and therapeutic implications in breast cancer

Mutations in genes that constitute the phosphatidylinositol 3-kinase (PI3K) pathway occur in >70% of breast cancers. Clinical and experimental evidence suggest that PI3K pathway activation promotes resistance to some of the current breast cancer therapies. PI3K is a major signaling hub downstream...

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Detalles Bibliográficos
Autores principales:	Miller, Todd W, Rexer, Brent N, Garrett, Joan T, Arteaga, Carlos L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315683/ https://www.ncbi.nlm.nih.gov/pubmed/22114931 http://dx.doi.org/10.1186/bcr3039

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