Synemin promotes AKT-dependent glioblastoma cell proliferation by antagonizing PP2A

The intermediate filament protein synemin is present in astrocyte progenitors and glioblastoma cells but not in mature astrocytes. Here we demonstrate a role for synemin in enhancing glioblastoma cell proliferation and clonogenic survival, as synemin RNA interference decreased both behaviors by indu...

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Detalles Bibliográficos
Autores principales: Pitre, Aaron, Davis, Nathan, Paul, Madhumita, Orr, A Wayne, Skalli, Omar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2012
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315805/
https://www.ncbi.nlm.nih.gov/pubmed/22337773
http://dx.doi.org/10.1091/mbc.E11-08-0685

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315805/
https://www.ncbi.nlm.nih.gov/pubmed/22337773
http://dx.doi.org/10.1091/mbc.E11-08-0685

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