3′-5′ Phosphoadenosine phosphate is an inhibitor of PARP-1 and a potential mediator of the lithium-dependent inhibition of PARP-1 in vivo

pAp (3′-5′ phosphoadenosine phosphate) is a by-product of sulfur and lipid metabolism and has been shown to have strong inhibitory properties on RNA catabolism. In the present paper we report a new target of pAp, PARP-1 [poly(ADP-ribose) polymerase 1], a key enzyme in the detection of DNA single-str...

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Detalles Bibliográficos
Autores principales: Toledano, Elie, Ogryzko, Vasily, Danchin, Antoine, Ladant, Daniel, Mechold, Undine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316155/
https://www.ncbi.nlm.nih.gov/pubmed/22240080
http://dx.doi.org/10.1042/BJ20111057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316155/
https://www.ncbi.nlm.nih.gov/pubmed/22240080
http://dx.doi.org/10.1042/BJ20111057

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