Modulation of γ-Secretase Activity by Multiple Enzyme-Substrate Interactions: Implications in Pathogenesis of Alzheimer's Disease

BACKGROUND: We describe molecular processes that can facilitate pathogenesis of Alzheimer's disease (AD) by analyzing the catalytic cycle of a membrane-imbedded protease γ-secretase, from the initial interaction with its C99 substrate to the final release of toxic Aβ peptides. RESULTS: The C-te...

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Detalles Bibliográficos
Autores principales: Svedružić, Željko M., Popović, Katarina, Smoljan, Ivana, Šendula-Jengić, Vesna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316526/
https://www.ncbi.nlm.nih.gov/pubmed/22479317
http://dx.doi.org/10.1371/journal.pone.0032293

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316526/
https://www.ncbi.nlm.nih.gov/pubmed/22479317
http://dx.doi.org/10.1371/journal.pone.0032293

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