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Protein Quality Control Disruption by PKCβII in Heart Failure; Rescue by the Selective PKCβII Inhibitor, βIIV5-3

Myocardial remodeling and heart failure (HF) are common sequelae of many forms of cardiovascular disease and a leading cause of mortality worldwide. Accumulation of damaged cardiac proteins in heart failure has been described. However, how protein quality control (PQC) is regulated and its contribut...

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Detalles Bibliográficos
Autores principales: Ferreira, Julio C. B., Boer, Berta Napchan, Grinberg, Max, Brum, Patricia Chakur, Mochly-Rosen, Daria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316563/
https://www.ncbi.nlm.nih.gov/pubmed/22479367
http://dx.doi.org/10.1371/journal.pone.0033175