Tyrosine Phosphorylation of the E3 Ubiquitin Ligase TRIM21 Positively Regulates Interaction with IRF3 and Hence TRIM21 Activity

Patients suffering from Systemic Lupus Erythematous (SLE) have elevated type I interferon (IFN) levels which correlate with disease activity and severity. TRIM21, an autoantigen associated with SLE, has been identified as an ubiquitin E3 ligase that targets the transcription factor IRF3 in order to...

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Detalles Bibliográficos
Autores principales: Stacey, Kevin B., Breen, Eamon, Jefferies, Caroline A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316593/
https://www.ncbi.nlm.nih.gov/pubmed/22479513
http://dx.doi.org/10.1371/journal.pone.0034041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316593/
https://www.ncbi.nlm.nih.gov/pubmed/22479513
http://dx.doi.org/10.1371/journal.pone.0034041

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