Cdt1 Is Differentially Targeted for Degradation by Anticancer Chemotherapeutic Drugs

BACKGROUND: Maintenance of genome integrity is crucial for the propagation of the genetic information. Cdt1 is a major component of the pre-replicative complex, which controls once per cell cycle DNA replication. Upon DNA damage, Cdt1 is rapidly targeted for degradation. This targeting has been sugg...

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Detalles Bibliográficos
Autores principales: Stathopoulou, Athanasia, Roukos, Vassilis, Petropoulou, Chariklia, Kotsantis, Panagiotis, Karantzelis, Nickolas, Nishitani, Hideo, Lygerou, Zoi, Taraviras, Stavros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316709/
https://www.ncbi.nlm.nih.gov/pubmed/22479651
http://dx.doi.org/10.1371/journal.pone.0034621

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316709/
https://www.ncbi.nlm.nih.gov/pubmed/22479651
http://dx.doi.org/10.1371/journal.pone.0034621

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