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Cdt1 Is Differentially Targeted for Degradation by Anticancer Chemotherapeutic Drugs
BACKGROUND: Maintenance of genome integrity is crucial for the propagation of the genetic information. Cdt1 is a major component of the pre-replicative complex, which controls once per cell cycle DNA replication. Upon DNA damage, Cdt1 is rapidly targeted for degradation. This targeting has been sugg...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316709/ https://www.ncbi.nlm.nih.gov/pubmed/22479651 http://dx.doi.org/10.1371/journal.pone.0034621 |