SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair

Breaking and sealing one strand of DNA is an inherent feature of chromosome metabolism to overcome torsional barriers. Failure to reseal broken DNA strands results in protein-linked DNA breaks, causing neurodegeneration in humans. This is typified by defects in tyrosyl DNA phosphodiesterase 1 (TDP1)...

Descripción completa

Detalles Bibliográficos
Autores principales: Hudson, Jessica J.R., Chiang, Shih-Chieh, Wells, Owen S., Rookyard, Chris, El-Khamisy, Sherif F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316882/
https://www.ncbi.nlm.nih.gov/pubmed/22415824
http://dx.doi.org/10.1038/ncomms1739

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316882/
https://www.ncbi.nlm.nih.gov/pubmed/22415824
http://dx.doi.org/10.1038/ncomms1739

Ejemplares similares