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SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair

Breaking and sealing one strand of DNA is an inherent feature of chromosome metabolism to overcome torsional barriers. Failure to reseal broken DNA strands results in protein-linked DNA breaks, causing neurodegeneration in humans. This is typified by defects in tyrosyl DNA phosphodiesterase 1 (TDP1)...

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Detalles Bibliográficos
Autores principales:	Hudson, Jessica J.R., Chiang, Shih-Chieh, Wells, Owen S., Rookyard, Chris, El-Khamisy, Sherif F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316882/ https://www.ncbi.nlm.nih.gov/pubmed/22415824 http://dx.doi.org/10.1038/ncomms1739

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