Structure of the pentameric ligand-gated ion channel ELIC cocrystallized with its competitive antagonist acetylcholine

ELIC, the pentameric ligand-gated ion channel from Erwinia chrysanthemi, is a prototype for Cys-loop receptors. Here we show that acetylcholine is a competitive antagonist for ELIC. We determine the acetylcholine–ELIC cocrystal structure to a 2.9-Å resolution and find that acetylcholine binding to a...

Descripción completa

Detalles Bibliográficos
Autores principales: Pan, Jianjun, Chen, Qiang, Willenbring, Dan, Yoshida, Ken, Tillman, Tommy, Kashlan, Ossama B., Cohen, Aina, Kong, Xiang-Peng, Xu, Yan, Tang, Pei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316889/
https://www.ncbi.nlm.nih.gov/pubmed/22395605
http://dx.doi.org/10.1038/ncomms1703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316889/
https://www.ncbi.nlm.nih.gov/pubmed/22395605
http://dx.doi.org/10.1038/ncomms1703

Ejemplares similares