Supratentorial and spinal pediatric ependymomas display a hypermethylated phenotype which includes the loss of tumor suppressor genes involved in the control of cell growth and death

Epigenetic alterations, including methylation, have been shown to be an important mechanism of gene silencing in cancer. Ependymoma has been well characterized at the DNA copy number and mRNA expression levels. However little is known about DNA methylation changes. To gain a more global view of the...

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Detalles Bibliográficos
Autores principales: Rogers, Hazel A., Kilday, John-Paul, Mayne, Cerys, Ward, Jennifer, Adamowicz-Brice, Martyna, Schwalbe, Ed C., Clifford, Steven C., Coyle, Beth, Grundy, Richard G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316934/
https://www.ncbi.nlm.nih.gov/pubmed/22109108
http://dx.doi.org/10.1007/s00401-011-0904-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316934/
https://www.ncbi.nlm.nih.gov/pubmed/22109108
http://dx.doi.org/10.1007/s00401-011-0904-1

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