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Aggregation of αSynuclein promotes progressive in vivo neurotoxicity in adult rat dopaminergic neurons
Fibrillar αSynuclein is the major constituent of Lewy bodies and Lewy neurites, the protein deposits characteristic for Parkinson’s disease (PD). Multiplications of the αSynuclein gene, as well as point mutations cause familial PD. However, the exact role of αSynuclein in neurodegeneration remains u...
Autores principales: | Taschenberger, Grit, Garrido, Manuel, Tereshchenko, Yuliya, Bähr, Mathias, Zweckstetter, Markus, Kügler, Sebastian |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316935/ https://www.ncbi.nlm.nih.gov/pubmed/22167382 http://dx.doi.org/10.1007/s00401-011-0926-8 |
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