GRP78 Protein Expression in Ovarian Cancer Patients and Perspectives for a Drug-Targeting Approach

Glucose-regulated protein of 78 kD (GRP78) is a chaperone protein mainly located in the endoplasmic reticulum (ER). This protein is normally present at low levels in adult cells but its expression is triggered by ER stress including glucose deprivation and hypoxia. In tumor cells, it is overexpresse...

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Detalles Bibliográficos
Autores principales: Delie, Florence, Petignat, Patrick, Cohen, Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317113/
https://www.ncbi.nlm.nih.gov/pubmed/22481929
http://dx.doi.org/10.1155/2012/468615
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author Delie, Florence
Petignat, Patrick
Cohen, Marie
author_facet Delie, Florence
Petignat, Patrick
Cohen, Marie
author_sort Delie, Florence
collection PubMed
description Glucose-regulated protein of 78 kD (GRP78) is a chaperone protein mainly located in the endoplasmic reticulum (ER). This protein is normally present at low levels in adult cells but its expression is triggered by ER stress including glucose deprivation and hypoxia. In tumor cells, it is overexpressed with fraction of protein found at the cell surface. This paper presents the physiology of GRP78 in the context of ovarian cancer and its potential use as drug delivery systems targeting ovarian cancer cell.
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spelling pubmed-33171132012-04-05 GRP78 Protein Expression in Ovarian Cancer Patients and Perspectives for a Drug-Targeting Approach Delie, Florence Petignat, Patrick Cohen, Marie J Oncol Review Article Glucose-regulated protein of 78 kD (GRP78) is a chaperone protein mainly located in the endoplasmic reticulum (ER). This protein is normally present at low levels in adult cells but its expression is triggered by ER stress including glucose deprivation and hypoxia. In tumor cells, it is overexpressed with fraction of protein found at the cell surface. This paper presents the physiology of GRP78 in the context of ovarian cancer and its potential use as drug delivery systems targeting ovarian cancer cell. Hindawi Publishing Corporation 2012 2012-03-18 /pmc/articles/PMC3317113/ /pubmed/22481929 http://dx.doi.org/10.1155/2012/468615 Text en Copyright © 2012 Florence Delie et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Delie, Florence
Petignat, Patrick
Cohen, Marie
GRP78 Protein Expression in Ovarian Cancer Patients and Perspectives for a Drug-Targeting Approach
title GRP78 Protein Expression in Ovarian Cancer Patients and Perspectives for a Drug-Targeting Approach
title_full GRP78 Protein Expression in Ovarian Cancer Patients and Perspectives for a Drug-Targeting Approach
title_fullStr GRP78 Protein Expression in Ovarian Cancer Patients and Perspectives for a Drug-Targeting Approach
title_full_unstemmed GRP78 Protein Expression in Ovarian Cancer Patients and Perspectives for a Drug-Targeting Approach
title_short GRP78 Protein Expression in Ovarian Cancer Patients and Perspectives for a Drug-Targeting Approach
title_sort grp78 protein expression in ovarian cancer patients and perspectives for a drug-targeting approach
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317113/
https://www.ncbi.nlm.nih.gov/pubmed/22481929
http://dx.doi.org/10.1155/2012/468615
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