Exendin-4 Protects MIN6 Cells from t-BHP-Induced Apoptosis via IRE1-JNK-Caspase-3 Signaling

Objectives. This study aimed to explore the effect of exendin-4 on t-BHP-induced apoptosis in pancreatic β cells and the mechanism of action. Methods. Murine MIN6 pancreatic β cells were treated with exendin-4 in the presence or absence of tert-butyl hydroperoxide (t-BHP). Cell survival was assessed...

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Detalles Bibliográficos
Autores principales: Chen, Wen-Jia, Wang, Lin-Xi, Wang, Yan-Ping, Chen, Zhou, Liu, Xiao-Ying, Liu, Xiao-Hong, Liu, Li-Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317221/
https://www.ncbi.nlm.nih.gov/pubmed/22518128
http://dx.doi.org/10.1155/2012/549081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317221/
https://www.ncbi.nlm.nih.gov/pubmed/22518128
http://dx.doi.org/10.1155/2012/549081

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