Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy

Adenosine monophosphate-activated protein kinase (AMPK) acts as a major sensor of cellular energy status in cancers and is critically involved in cell sensitivity to anticancer agents. Here, we showed that AMPK was inactivated in lymphoma and related to the upregulation of the mammalian target of ra...

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Detalles Bibliográficos
Autores principales: Shi, W-Y, Xiao, D, Wang, L, Dong, L-H, Yan, Z-X, Shen, Z-X, Chen, S-J, Chen, Y, Zhao, W-L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317343/
https://www.ncbi.nlm.nih.gov/pubmed/22378068
http://dx.doi.org/10.1038/cddis.2012.13

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317343/
https://www.ncbi.nlm.nih.gov/pubmed/22378068
http://dx.doi.org/10.1038/cddis.2012.13

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