C16 ceramide is crucial for triacylglycerol-induced apoptosis in macrophages

Triacylglycerol (TG) accumulation caused by adipose triglyceride lipase (ATGL) deficiency or very low-density lipoprotein (VLDL) loading of wild-type (Wt) macrophages results in mitochondrial-mediated apoptosis. This phenotype is correlated to depletion of Ca(2+) from the endoplasmic reticulum (ER),...

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Detalles Bibliográficos
Autores principales: Aflaki, E, Doddapattar, P, Radović, B, Povoden, S, Kolb, D, Vujić, N, Wegscheider, M, Koefeler, H, Hornemann, T, Graier, W F, Malli, R, Madeo, F, Kratky, D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317349/
https://www.ncbi.nlm.nih.gov/pubmed/22419109
http://dx.doi.org/10.1038/cddis.2012.17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317349/
https://www.ncbi.nlm.nih.gov/pubmed/22419109
http://dx.doi.org/10.1038/cddis.2012.17

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