Toll-Like Receptor 7 Agonist Therapy with Imidazoquinoline Enhances Cancer Cell Death and Increases Lymphocytic Infiltration and Proinflammatory Cytokine Production in Established Tumors of a Renal Cell Carcinoma Mouse Model

Imidazoquinolines are synthetic toll-like receptor 7 and 8 agonists and potent dendritic cell activators with established anticancer activity. Here we test the hypothesis that imidazoquinoline has in vivo efficacy within established renal cell carcinoma (RCC) tumors. Immunocompetent mice bearing syn...

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Detalles Bibliográficos
Autores principales: Kauffman, Eric C., Liu, Huixian, Schwartz, Michael J., Scherr, Douglas S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317372/
https://www.ncbi.nlm.nih.gov/pubmed/22481916
http://dx.doi.org/10.1155/2012/103298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317372/
https://www.ncbi.nlm.nih.gov/pubmed/22481916
http://dx.doi.org/10.1155/2012/103298

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