FTS and 2-DG induce pancreatic cancer cell death and tumor shrinkage in mice

The Ras inhibitor S-trans-trans farnesylthiosalicylic acid (FTS) inhibits active Ras, which controls cell proliferation, differentiation, survival, and metabolism. FTS also inhibits HIF1α expression in cancer cells, leading to an energy crisis. The synthetic glucose analog 2-deoxy-D-glucose (2-DG),...

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Detalles Bibliográficos
Autores principales: Goldberg, L, Israeli, R, Kloog, Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317504/
https://www.ncbi.nlm.nih.gov/pubmed/22419113
http://dx.doi.org/10.1038/cddis.2012.24

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317504/
https://www.ncbi.nlm.nih.gov/pubmed/22419113
http://dx.doi.org/10.1038/cddis.2012.24

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