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Synthesis and Biological Activities of a 3′-Azido Analogue of Doxorubicin Against Drug-Resistant Cancer Cells

Doxorubicin (DOX), an anthracycline antibiotic, is one of the most active anticancer chemotherapeutic agents. The clinical use of DOX, however, is limited by the dose-dependant P-glycoprotein (P-gp)-mediated resistance. Herein, a 3′-azido analogue of DOX (ADOX) was prepared from daunorubicin (DNR)....

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Detalles Bibliográficos
Autores principales: Yu, Shuwen, Zhang, Guisheng, Zhang, Wenpeng, Luo, Huanhua, Qiu, Liyun, Liu, Qingfeng, Sun, Duxin, Wang, Peng-George, Wang, Fengshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317735/
https://www.ncbi.nlm.nih.gov/pubmed/22489175
http://dx.doi.org/10.3390/ijms13033671