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Ovastacin, a cortical granule protease, cleaves ZP2 in the zona pellucida to prevent polyspermy
The mouse zona pellucida is composed of three glycoproteins (ZP1, ZP2, and ZP3), of which ZP2 is proteolytically cleaved after gamete fusion to prevent polyspermy. This cleavage is associated with exocytosis of cortical granules that are peripherally located subcellular organelles unique to ovulated...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317803/ https://www.ncbi.nlm.nih.gov/pubmed/22472438 http://dx.doi.org/10.1083/jcb.201112094 |