Palmitoylation and membrane cholesterol stabilize μ-opioid receptor homodimerization and G protein coupling

BACKGROUND: A cholesterol-palmitoyl interaction has been reported to occur in the dimeric interface of the β(2)-adrenergic receptor crystal structure. We sought to investigate whether a similar phenomenon could be observed with μ-opioid receptor (OPRM1), and if so, to assess the role of cholesterol...

Descripción completa

Detalles Bibliográficos
Autores principales: Zheng, Hui, Pearsall, Elizabeth A, Hurst, Dow P, Zhang, Yuhan, Chu, Ji, Zhou, Yali, Reggio, Patricia H, Loh, Horace H, Law, Ping-Yee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317874/
https://www.ncbi.nlm.nih.gov/pubmed/22429589
http://dx.doi.org/10.1186/1471-2121-13-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317874/
https://www.ncbi.nlm.nih.gov/pubmed/22429589
http://dx.doi.org/10.1186/1471-2121-13-6

Ejemplares similares