Protein Tyrosine Phosphatase 1B Deficiency Potentiates PERK/eIF2α Signaling in Brown Adipocytes

BACKGROUND: Protein-tyrosine phosphatase 1B (PTP1B) is a physiological regulator of glucose homeostasis and body mass, and has been implicated in endoplasmic reticulum (ER) stress. Herein, we assess the role of PTP1B in ER stress in brown adipocytes, which are key regulators of thermogenesis and met...

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Detalles Bibliográficos
Autores principales: Bettaieb, Ahmed, Matsuo, Kosuke, Matsuo, Izumi, Wang, Shuo, Melhem, Ramzi, Koromilas, Antonis E., Haj, Fawaz G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317973/
https://www.ncbi.nlm.nih.gov/pubmed/22509299
http://dx.doi.org/10.1371/journal.pone.0034412

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317973/
https://www.ncbi.nlm.nih.gov/pubmed/22509299
http://dx.doi.org/10.1371/journal.pone.0034412

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