The tetramethoxyflavone zapotin selectively activates protein kinase C epsilon, leading to its down-modulation accompanied by Bcl-2, c-Jun and c-Fos decrease

Zapotin, a tetramethoxyflavone, is a natural compound with a wide spectrum of activities in neoplastic cells. Protein kinase C epsilon (PKCε) has been shown to be oncogenic, with the ability to increase cell migration, invasion and survival of tumor cells. Here we report that zapotin inhibits cell p...

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Detalles Bibliográficos
Autores principales: Toton, Ewa, Lisiak, Natalia, Rubis, Blazej, Budzianowski, Jaromir, Gruber, Peter, Hofmann, Johann, Rybczynska, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2012
Materias:
Molecular and Cellular Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318187/
https://www.ncbi.nlm.nih.gov/pubmed/22381066
http://dx.doi.org/10.1016/j.ejphar.2012.02.020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318187/
https://www.ncbi.nlm.nih.gov/pubmed/22381066
http://dx.doi.org/10.1016/j.ejphar.2012.02.020

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