Biochemical Inhibition of the Acetyltransferases ATase1 and ATase2 Reduces β-Secretase (BACE1) Levels and Aβ Generation

The cellular levels of β-site APP cleaving enzyme 1 (BACE1), the rate-limiting enzyme for the generation of the Alzheimer disease (AD) amyloid β-peptide (Aβ), are tightly regulated by two ER-based acetyl-CoA:lysine acetyltransferases, ATase1 and ATase2. Here we report that both acetyltransferases ar...

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Detalles Bibliográficos
Autores principales: Ding, Yun, Ko, Mi Hee, Pehar, Mariana, Kotch, Frank, Peters, Noel R., Luo, Yun, Salamat, Shahriar M., Puglielli, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Neurobiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318698/
https://www.ncbi.nlm.nih.gov/pubmed/22267734
http://dx.doi.org/10.1074/jbc.M111.310136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318698/
https://www.ncbi.nlm.nih.gov/pubmed/22267734
http://dx.doi.org/10.1074/jbc.M111.310136

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