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Biochemical Inhibition of the Acetyltransferases ATase1 and ATase2 Reduces β-Secretase (BACE1) Levels and Aβ Generation

The cellular levels of β-site APP cleaving enzyme 1 (BACE1), the rate-limiting enzyme for the generation of the Alzheimer disease (AD) amyloid β-peptide (Aβ), are tightly regulated by two ER-based acetyl-CoA:lysine acetyltransferases, ATase1 and ATase2. Here we report that both acetyltransferases ar...

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Detalles Bibliográficos
Autores principales:	Ding, Yun, Ko, Mi Hee, Pehar, Mariana, Kotch, Frank, Peters, Noel R., Luo, Yun, Salamat, Shahriar M., Puglielli, Luigi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2012
Materias:	Neurobiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318698/ https://www.ncbi.nlm.nih.gov/pubmed/22267734 http://dx.doi.org/10.1074/jbc.M111.310136

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