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Anti-Inflammatory Activities of Cinnamomum cassia Constituents In Vitro and In Vivo
We have investigated the anti-inflammatory effects of Cinnamomum cassia constituents (cinnamic aldehyde, cinnamic alcohol, cinnamic acid, and coumarin) using lipopolysaccharide (LPS)-stimulated mouse macrophage (RAW264.7) and carrageenan (Carr)-induced mouse paw edema model. When RAW264.7 macrophage...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318905/ https://www.ncbi.nlm.nih.gov/pubmed/22536283 http://dx.doi.org/10.1155/2012/429320 |
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author | Liao, Jung-Chun Deng, Jeng-Shyan Chiu, Chuan-Sung Hou, Wen-Chi Huang, Shyh-Shyun Shie, Pei-Hsin Huang, Guang-Jhong |
author_facet | Liao, Jung-Chun Deng, Jeng-Shyan Chiu, Chuan-Sung Hou, Wen-Chi Huang, Shyh-Shyun Shie, Pei-Hsin Huang, Guang-Jhong |
author_sort | Liao, Jung-Chun |
collection | PubMed |
description | We have investigated the anti-inflammatory effects of Cinnamomum cassia constituents (cinnamic aldehyde, cinnamic alcohol, cinnamic acid, and coumarin) using lipopolysaccharide (LPS)-stimulated mouse macrophage (RAW264.7) and carrageenan (Carr)-induced mouse paw edema model. When RAW264.7 macrophages were treated with cinnamic aldehyde together with LPS, a significant concentration-dependent inhibition of nitric oxide (NO), tumor necrosis factor (TNF-α), and prostaglandin E2 (PGE(2)) levels productions were detected. Western blotting revealed that cinnamic aldehyde blocked protein expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), nuclear transcription factor kappa B (NF-κB), and IκBα, significantly. In the anti-inflammatory test, cinnamic aldehyde decreased the paw edema after Carr administration, and increased the activities of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) in the paw tissue. We also demonstrated cinnamic aldehyde attenuated the malondialdehyde (MDA) level and myeloperoxidase (MPO) activity in the edema paw after Carr injection. Cinnamic aldehyde decreased the NO, TNF-α, and PGE(2) levels on the serum level after Carr injection. Western blotting revealed that cinnamic aldehyde decreased Carr-induced iNOS, COX-2, and NF-κB expressions in the edema paw. These findings demonstrated that cinnamic aldehyde has excellent anti-inflammatory activities and thus has great potential to be used as a source for natural health products. |
format | Online Article Text |
id | pubmed-3318905 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33189052012-04-25 Anti-Inflammatory Activities of Cinnamomum cassia Constituents In Vitro and In Vivo Liao, Jung-Chun Deng, Jeng-Shyan Chiu, Chuan-Sung Hou, Wen-Chi Huang, Shyh-Shyun Shie, Pei-Hsin Huang, Guang-Jhong Evid Based Complement Alternat Med Research Article We have investigated the anti-inflammatory effects of Cinnamomum cassia constituents (cinnamic aldehyde, cinnamic alcohol, cinnamic acid, and coumarin) using lipopolysaccharide (LPS)-stimulated mouse macrophage (RAW264.7) and carrageenan (Carr)-induced mouse paw edema model. When RAW264.7 macrophages were treated with cinnamic aldehyde together with LPS, a significant concentration-dependent inhibition of nitric oxide (NO), tumor necrosis factor (TNF-α), and prostaglandin E2 (PGE(2)) levels productions were detected. Western blotting revealed that cinnamic aldehyde blocked protein expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), nuclear transcription factor kappa B (NF-κB), and IκBα, significantly. In the anti-inflammatory test, cinnamic aldehyde decreased the paw edema after Carr administration, and increased the activities of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) in the paw tissue. We also demonstrated cinnamic aldehyde attenuated the malondialdehyde (MDA) level and myeloperoxidase (MPO) activity in the edema paw after Carr injection. Cinnamic aldehyde decreased the NO, TNF-α, and PGE(2) levels on the serum level after Carr injection. Western blotting revealed that cinnamic aldehyde decreased Carr-induced iNOS, COX-2, and NF-κB expressions in the edema paw. These findings demonstrated that cinnamic aldehyde has excellent anti-inflammatory activities and thus has great potential to be used as a source for natural health products. Hindawi Publishing Corporation 2012 2012-03-27 /pmc/articles/PMC3318905/ /pubmed/22536283 http://dx.doi.org/10.1155/2012/429320 Text en Copyright © 2012 Jung-Chun Liao et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Liao, Jung-Chun Deng, Jeng-Shyan Chiu, Chuan-Sung Hou, Wen-Chi Huang, Shyh-Shyun Shie, Pei-Hsin Huang, Guang-Jhong Anti-Inflammatory Activities of Cinnamomum cassia Constituents In Vitro and In Vivo |
title | Anti-Inflammatory Activities of Cinnamomum cassia Constituents In Vitro and In Vivo
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title_full | Anti-Inflammatory Activities of Cinnamomum cassia Constituents In Vitro and In Vivo
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title_fullStr | Anti-Inflammatory Activities of Cinnamomum cassia Constituents In Vitro and In Vivo
|
title_full_unstemmed | Anti-Inflammatory Activities of Cinnamomum cassia Constituents In Vitro and In Vivo
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title_short | Anti-Inflammatory Activities of Cinnamomum cassia Constituents In Vitro and In Vivo
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title_sort | anti-inflammatory activities of cinnamomum cassia constituents in vitro and in vivo |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318905/ https://www.ncbi.nlm.nih.gov/pubmed/22536283 http://dx.doi.org/10.1155/2012/429320 |
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