Estradiol Triggers Sonic-hedgehog–induced Angiogenesis During Peripheral Nerve Regeneration by Downregulating Hedgehog-interacting Protein

Both estradiol (E2) and Sonic Hedgehog (Shh) contribute to angiogenesis and nerve regeneration. Here, we investigated whether E2 improves the recovery of injured nerves by downregulating the Shh-inhibitor Hedgehog-interacting Protein (HIP) and increasing Shh-induced angiogenesis. Mice were treated w...

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Detalles Bibliográficos
Autores principales: Sekiguchi, Haruki, Ii, Masaaki, Jujo, Kentaro, Renault, Marie-Ange, Thorne, Tina, Clarke, Trevor, Ito, Aiko, Tanaka, Toshikazu, Klyachko, Ekaterina, Tabata, Yasuhiko, Hagiwara, Nobuhisa, Losordo, Douglas W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319330/
https://www.ncbi.nlm.nih.gov/pubmed/22330336
http://dx.doi.org/10.1038/labinvest.2012.6

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