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Cleavage of pyrene-stabilized RNA bulge loops by trans-(±)-cyclohexane-1,2-diamine

Chemical agents that cleave HIV genome can be potentially used for anti-HIV therapy. In this report, the cleavage of the upper stem-loop region of HIV-1 TAR RNA was studied in a variety of buffers containing organic catalysts. trans-(±)-Cyclohexane-1,2-diamine was found to cleave the RNA with the hi...

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Detalles Bibliográficos
Autores principales:	Patel, Sejal, Rana, Jagruti, Roy, Jyoti, Huang, Haidong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319420/ https://www.ncbi.nlm.nih.gov/pubmed/22244351 http://dx.doi.org/10.1186/1752-153X-6-3

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