Cdk5 and Mekk1 mediate a Pro-Apoptotic Signaling Response to Endoplasmic Reticulum Stress in a Drosophila Model of Autosomal Dominant Retinitis Pigmentosa

Chronic stress in the endoplasmic reticulum (ER) underlies many degenerative and metabolic diseases involving apoptosis of vital cells. A well-established example is Autosomal Dominant Retinitis Pigmentosa (ADRP), an age-related retinal degenerative disease caused by mutant rhodopsins (1, 2). Simila...

Descripción completa

Detalles Bibliográficos
Autores principales: Kang, Min-Ji, Chung, Jaehoon, Ryoo, Hyung Don
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319494/
https://www.ncbi.nlm.nih.gov/pubmed/22388889
http://dx.doi.org/10.1038/ncb2447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319494/
https://www.ncbi.nlm.nih.gov/pubmed/22388889
http://dx.doi.org/10.1038/ncb2447

Ejemplares similares