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Comparative Analysis of Mycobacterium tuberculosis pe and ppe Genes Reveals High Sequence Variation and an Apparent Absence of Selective Constraints

Mycobacterium tuberculosis complex (MTBC) genomes contain 2 large gene families termed pe and ppe. The function of pe/ppe proteins remains enigmatic but studies suggest that they are secreted or cell surface associated and are involved in bacterial virulence. Previous studies have also shown that so...

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Detalles Bibliográficos
Autores principales:	McEvoy, Christopher R. E., Cloete, Ruben, Müller, Borna, Schürch, Anita C., van Helden, Paul D., Gagneux, Sebastien, Warren, Robin M., Gey van Pittius, Nicolaas C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319526/ https://www.ncbi.nlm.nih.gov/pubmed/22496726 http://dx.doi.org/10.1371/journal.pone.0030593

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