Dysfunction of Organic Anion Transporting Polypeptide 1a1 Alters Intestinal Bacteria and Bile Acid Metabolism in Mice

Organic anion transporting polypeptide 1a1 (Oatp1a1) is predominantly expressed in liver and is able to transport bile acids (BAs) in vitro. Male Oatp1a1-null mice have increased concentrations of taurodeoxycholic acid (TDCA), a secondary BA generated by intestinal bacteria, in both serum and livers...

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Detalles Bibliográficos
Autores principales: Zhang, Youcai, Limaye, Pallavi B., Lehman-McKeeman, Lois D., Klaassen, Curtis D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319588/
https://www.ncbi.nlm.nih.gov/pubmed/22496825
http://dx.doi.org/10.1371/journal.pone.0034522

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319588/
https://www.ncbi.nlm.nih.gov/pubmed/22496825
http://dx.doi.org/10.1371/journal.pone.0034522

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