Differential Epigenetic Regulation of TOX Subfamily High Mobility Group Box Genes in Lung and Breast Cancers

Aberrant cytosine methylation affects regulation of hundreds of genes during cancer development. In this study, a novel aberrantly hypermethylated CpG island in cancer was discovered within the TOX2 promoter. TOX2 was unmethylated in normal cells but 28% lung (n = 190) and 23% breast (n = 80) tumors...

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Detalles Bibliográficos
Autores principales: Tessema, Mathewos, Yingling, Christin M., Grimes, Marcie J., Thomas, Cynthia L., Liu, Yushi, Leng, Shuguang, Joste, Nancy, Belinsky, Steven A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319602/
https://www.ncbi.nlm.nih.gov/pubmed/22496870
http://dx.doi.org/10.1371/journal.pone.0034850

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319602/
https://www.ncbi.nlm.nih.gov/pubmed/22496870
http://dx.doi.org/10.1371/journal.pone.0034850

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