Reduced Axonal Transport and Increased Excitotoxic Retinal Ganglion Cell Degeneration in Mice Transgenic for Human Mutant P301S Tau

The effects of tau hyperphosphorylation and aggregation on axonal transport were investigated in the optic nerve of mice transgenic for human mutant P301S tau. Transport was examined using cholera toxin B tracing. Retrograde transport was reduced in transgenic mice at 3 and 5 months of age, when com...

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Detalles Bibliográficos
Autores principales: Bull, Natalie D., Guidi, Alessandra, Goedert, Michel, Martin, Keith R., Spillantini, Maria Grazia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319610/
https://www.ncbi.nlm.nih.gov/pubmed/22496848
http://dx.doi.org/10.1371/journal.pone.0034724

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319610/
https://www.ncbi.nlm.nih.gov/pubmed/22496848
http://dx.doi.org/10.1371/journal.pone.0034724

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