A Telomere Dependent DNA Damage Checkpoint Induced by Prolonged Mitotic Arrest

Telomere shortening and disruption of telomeric components are pathways that induce telomere deprotection. Here we describe another pathway, where prolonged mitotic arrest induces damage signals at telomeres in human cells. Exposure to microtubule drugs, kinesin inhibitors, proteasome inhibitors or...

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Detalles Bibliográficos
Autores principales: Hayashi, Makoto T., Cesare, Anthony J., Fitzpatrick, James A. J., Lazzerini-Denchi, Eros, Karlseder, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319806/
https://www.ncbi.nlm.nih.gov/pubmed/22407014
http://dx.doi.org/10.1038/nsmb.2245

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319806/
https://www.ncbi.nlm.nih.gov/pubmed/22407014
http://dx.doi.org/10.1038/nsmb.2245

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