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The Effects of the KCNQ Openers Retigabine and Flupirtine on Myotonia in Mammalian Skeletal Muscle Induced by a Chloride Channel Blocker

The purpose of this study was to investigate the effect of KCNQ (potassium channel, voltage-gated, KQT-like subfamily) openers in preventing myotonia caused by anthracene-9-carboxylic acid (9-AC, a chloride channel blocker). An animal model of myotonia can be elicited in murine skeletal muscle by 9-...

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Detalles Bibliográficos
Autores principales: Su, Tzu-Rong, Zei, Wen-Shan, Su, Ching-Chyuan, Hsiao, George, Lin, Min-Jon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320144/
https://www.ncbi.nlm.nih.gov/pubmed/22536291
http://dx.doi.org/10.1155/2012/803082