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Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors
The zinc-dependent mammalian histone deacetylase (HDAC) family comprises 11 enzymes, which have specific and critical functions in development and tissue homeostasis. Mounting evidence points to a link between misregulated HDAC activity and many oncologic and nononcologic diseases. Thus the developm...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320549/ https://www.ncbi.nlm.nih.gov/pubmed/22414492 http://dx.doi.org/10.1186/1868-7083-4-5 |