The mGluR5 antagonist AFQ056 does not affect methylation and transcription of the mutant FMR1 gene in vitro

BACKGROUND: Fragile X syndrome (FXS), the leading cause of inherited mental retardation, is due to expansion and methylation of a CGG sequence in the FMR1 gene, which result in its silencing and consequent absence of FMRP protein. This absence causes loss of repression of metabotropic glutamate rece...

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Detalles Bibliográficos
Autores principales: Tabolacci, Elisabetta, Pirozzi, Filomena, Gomez-Mancilla, Baltazar, Gasparini, Fabrizio, Neri, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320553/
https://www.ncbi.nlm.nih.gov/pubmed/22397687
http://dx.doi.org/10.1186/1471-2350-13-13

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320553/
https://www.ncbi.nlm.nih.gov/pubmed/22397687
http://dx.doi.org/10.1186/1471-2350-13-13

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