Cargando…

Parameters in Dynamic Models of Complex Traits are Containers of Missing Heritability

Polymorphisms identified in genome-wide association studies of human traits rarely explain more than a small proportion of the heritable variation, and improving this situation within the current paradigm appears daunting. Given a well-validated dynamic model of a complex physiological trait, a subs...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Yunpeng, Gjuvsland, Arne B., Vik, Jon Olav, Smith, Nicolas P., Hunter, Peter J., Omholt, Stig W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320574/ https://www.ncbi.nlm.nih.gov/pubmed/22496634 http://dx.doi.org/10.1371/journal.pcbi.1002459

Ejemplares similares

Effect of Regulatory Architecture on Broad versus Narrow Sense Heritability
por: Wang, Yunpeng, et al.
Publicado: (2013)

Hierarchical Cluster-based Partial Least Squares Regression (HC-PLSR) is an efficient tool for metamodelling of nonlinear dynamic models
por: Tøndel, Kristin, et al.
Publicado: (2011)

Bridging the genotype–phenotype gap: what does it take?
por: Gjuvsland, Arne B, et al.
Publicado: (2013)

Genotype–Phenotype Map Characteristics of an In silico Heart Cell
por: Vik, Jon Olav, et al.
Publicado: (2011)

Monotonicity is a key feature of genotype-phenotype maps
por: Gjuvsland, Arne B., et al.
Publicado: (2013)

Multi-way metamodelling facilitates insight into the complex input-output maps of nonlinear dynamic models
por: Tøndel, Kristin, et al.
Publicado: (2012)

Beyond Missing Heritability: Prediction of Complex Traits
por: Makowsky, Robert, et al.
Publicado: (2011)

Haplotype Heritability Mapping Method Uncovers Missing Heritability of Complex Traits
por: Shirali, Masoud, et al.
Publicado: (2018)

Threshold-dominated regulation hides genetic variation in gene expression networks
por: Gjuvsland, Arne B, et al.
Publicado: (2007)

Allele Interaction – Single Locus Genetics Meets Regulatory Biology
por: Gjuvsland, Arne B., et al.
Publicado: (2010)

Estimates of missing heritability for complex traits in Brown Swiss cattle
por: Román-Ponce, Sergio-Iván, et al.
Publicado: (2014)

Leveraging population admixture to explain missing heritability of complex traits
por: Zaitlen, Noah, et al.
Publicado: (2014)

Towards a quantitative understanding of the MITF-PIAS3-STAT3 connection
por: Thingnes, Josef, et al.
Publicado: (2012)

Nonlinear regulation enhances the phenotypic expression of trans-acting genetic polymorphisms
por: Gjuvsland, Arne B, et al.
Publicado: (2007)

Finding the missing heritability in pediatric obesity: the contribution of genome-wide complex trait analysis
por: Llewellyn, C H, et al.
Publicado: (2013)

Trait Variation in Yeast Is Defined by Population History
por: Warringer, Jonas, et al.
Publicado: (2011)

Regional heritability mapping method helps explain missing heritability of blood lipid traits in isolated populations
por: Shirali, M, et al.
Publicado: (2016)

The curse of the missing heritability
por: Shen, Xia
Publicado: (2013)

Heritability and Genetic Parameters for Semen Traits in Australian Sheep
por: Hodge, Marnie J., et al.
Publicado: (2022)

Epigenetic inheritance and the missing heritability
por: Trerotola, Marco, et al.
Publicado: (2015)

Solving the missing heritability problem
por: Young, Alexander I.
Publicado: (2019)

Missing heritability and where to find it
por: Girirajan, Santhosh
Publicado: (2017)

Ancient Evolutionary Trade-Offs between Yeast Ploidy States
por: Zörgö, Enikö, et al.
Publicado: (2013)

Rare Variants in Transcript and Potential Regulatory Regions Explain a Small Percentage of the Missing Heritability of Complex Traits in Cattle
por: Gonzalez-Recio, Oscar, et al.
Publicado: (2015)

Re-evaluation of SNP heritability in complex human traits
por: Speed, Doug, et al.
Publicado: (2017)

Quantifying the contribution of Neanderthal introgression to the heritability of complex traits
por: McArthur, Evonne, et al.
Publicado: (2021)

Missing heritability and missing Fst of candidate genes: why does gene variation differ from trait variation in trees?
por: Kremer, Antoine
Publicado: (2011)

An Evolutionary Perspective on Epistasis and the Missing Heritability
por: Hemani, Gibran, et al.
Publicado: (2013)

Alzheimer’s Disease: Analyzing the Missing Heritability
por: Ridge, Perry G., et al.
Publicado: (2013)

The Human Microbiome and the Missing Heritability Problem
por: Sandoval-Motta, Santiago, et al.
Publicado: (2017)

Uncovering Missing Heritability in Rare Diseases
por: Maroilley, Tatiana, et al.
Publicado: (2019)

The missing heritability of familial colorectal cancer
por: Schubert, Stephanie A, et al.
Publicado: (2020)

Searching for solutions to the missing heritability problem
por: Pallares, Luisa F
Publicado: (2019)

The missing heritability in type 1 diabetes
por: Pang, Haipeng, et al.
Publicado: (2022)

Lessons from Model Organisms: Phenotypic Robustness and Missing Heritability in Complex Disease
por: Queitsch, Christine, et al.
Publicado: (2012)

Assessing the Heritability of Complex Traits in Humans: Methodological Challenges and Opportunities
por: Mayhew, Alexandra J., et al.
Publicado: (2017)

Genetic Interactions with Sex Make a Relatively Small Contribution to the Heritability of Complex Traits in Mice
por: Krohn, Jon, et al.
Publicado: (2014)

Dark Matter: Are Mice the Solution to Missing Heritability?
por: Parker, Clarissa C., et al.
Publicado: (2011)

Quantifying Missing Heritability at Known GWAS Loci
por: Gusev, Alexander, et al.
Publicado: (2013)

RNA: a possible contributor to the 'missing heritability’
por: Grandjean, Valérie, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_7kqtv7qshohiv5ruok5s2hlk90